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Loading controls are essential to ensure data reliability in your western blot. Learn about the three main considerations for loading control selection.
Information and case study data for the PTMScan Direct PI3K/Akt Service offered by CST, which allows for targeted screening of 105 proteins within the Akt pathway.
An interactive 3D molecular model depicting the cellular landscape of a nucleus and its various protein subsets including DNA Damage, Replication, Transcription, etc.
Cellular senescence is stable cell cycle arrest linked to aging and cancer and other disease states, including those associated with inflammation. It is induced by DNA damage, oncogenic signaling, and telomere shortening.
It was too difficult for scientists to uncover the peptides for which they enriched, so scientists from the Broad Institute and CST® created a new method.
Expert-reviewed diagram providing a current overview of the Senescence Signaling pathway with references to its role in cell cycle
Cellular senescence is a state of stable cell cycle arrest under which cells remain metabolically active, but no longer divide or respond to growth-promoting stimuli.
In response to a variety of environmental factors, cells may permanently cease proliferation and enter a state known as cellular senescence.
Senescent cells increase in number during aging and have been implicated in the decline of organismal function over time, as well as in the progression of age-related diseases.
Overview of apoptosis signaling networks, antibodies and related reagents, interactive pathway diagrams, and technical resources for apoptosis research.
Organelle markers for immunofluorescence analysis from CST Cell Signaling Technology
Cell states can be monitored using markers correlating to your process of interest. These assays and antibodies can be used to detect cell viability, senescence, proliferation, apoptosis, cytotoxicity and oxidative state.
Cellular senescence is defined by permanent cell cycle arrest. Senescent cells accumulate with age and contribute to normal aging and age-related disorders
Co-staining with multiple antibodies is a low-content form of multiplex analysis that be achieved using different host species or fluorophore conjugates.
There are many reasons to include a subcellular marker in your IF experiment: studying organelle-specific functions, assessing drug effects, and more.
Apoptosis is a regulated form of programmed cell death (PCD) that occurs without external influence.
Interested in studying senescence? Understanding cell cycle arrest is critical to many fields of research, including development, aging, and cancer.
Expert-reviewed interactive signaling pathways providing current overviews of the regulation of actin and microtubule dynamics, as well as links to products from CST.
Streamline your oncology therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
Expert-reviewed interactive pathway providing a current overview of Death Receptor Signaling.
Streamline your neurodegeneration therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
The PI3K / Akt Substrates Table provides a comprehensive list of demonstrated downstream targets of Akt phosphorylation.
Abnormal cell-cell communication, for example disrupted presynaptic input, as well as disrupted intracellular signaling contribute to the pathogenesis of neurodegenerative disease.
We have several antibodies for detecting the phosphorylation of ribosomal protein S6 (rpS6) at Ser235/236 that are validated for IF-IC with human samples. These are as follows:
We have several antibodies for detecting the phosphorylation of ribosomal protein S6 (rpS6) at Ser235/236 that are validated for IF-IC with mouse samples. These are Phospho-S6 Ribosomal Protein (Ser235/236) Antibody #2211, Phospho-S6 Ribosomal Protein (Ser235/236) (D57.2.2E) XP® Rabbit mAb #4858, Phospho-S6 Ribosomal Protein (Ser235/236) (91B2) Rabbit mAb #4857, Phospho-S6 Ribosomal Protein (Ser235/236) (2F9) Rabbit mAb #4856, and Phospho-S6 Ribosomal Protein (Ser235/236) (E2R1O) Mouse mAb #62016. All of these antibodies are suitable for immunofluorescence in mouse cells.
Expert-reviewed diagram providing a current overview of the Mechanisms of Fibrosis pathway with references to its role in adhesion
From social media and emails to grant proposals and research articles, scientists are expected to master a variety of academic writing styles.
Discover the power of flow cytometry in cellular analysis and biomarker detection. Click here to learn more
