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Measuring and comparing cell viability in your assays is important, whether it’s the data you’re pursuing or an important control in your experiment.
Apoptosis is a regulated form of programmed cell death (PCD) that occurs without external influence.
Cancer cells can resist death. They evade apoptosis, the mechanism that programs cell death once cells become damaged. Normally, apoptosis helps keep an organism healthy through growth and development, but cancer cells do not follow this process, no matter how abnormally they grow.
Pyroptosis is a type of programmed necrotic cell death activated by infections from bacteria, viruses, fungi or protozoa in the presence of PAMPs or DAMPs
Cell states can be monitored using markers correlating to your process of interest. These assays and antibodies can be used to detect cell viability, senescence, proliferation, apoptosis, cytotoxicity and oxidative state.
Apoptosis is a type of programmed cell death that occurs normally throughout the lifespan and can also occur in response to harmful stimuli. Apoptotic cells are identified by their altered morphology, caspase activation, and the presence of damaged DNA.
Apoptosis is a highly regulated form of programmed cell death that occurs in multicellular organisms throughout life and in response to cellular stress.
Cell viability is a measure of the proportion of live, healthy cells within a population. Assays to assess cell viability measure metabolic activity, ATP content, cell proliferation, or membrane integrity.
Ferroptosis is a form of programmed cell death characterized by condensed mitochondria, reduction in mitochondrial cristae, and increased membrane density.
Activated by pro-inflammatory signaling, ischemic injury or viral infection, necroptosis is a programmed regulated form of necrosis requiring RIP3 and MLKL
Regulation of cell death due to viral infection is important for host survival. In this series, we look at pathways regulated through cellular responses to viruses.
Streamline your neurodegeneration therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
A scientific resource for the START protein domain containing information on structure, function, and domain binding.
CST sponsored Science Webinar Series: Exploring Cell Signaling through Mass Spec: May 1, 2013. Hear the webinar (3 speakers), download slides and transcripts.
Learn how enzymatic digestion can help you get better ChIP results.
Tips to keep in mind when deciding between wet and semi dry transfer.
Cell behavior is a tightly regulated process where various signals work together to elicit a specific response. Unraveling these mechanisms allows us to understand how cells are regulated in a normal state.
Because characterized antibodies are one reason that many experimental results cannot be replicated, researchers expect rigorous validation from manufacturers.
As a company focused on cancer research, we planned a volunteering event with the American Cancer Society Hope Lodge.
Advancements in immunotherapeutics against cancer include receptor agonists, adoptive cell transfer, anti-cancer vaccines, and combination therapies.
An orthogonal antibody validation strategy is critical to verify existing validation data and identify any effects or artifacts that are directly related.
We created a set of guides from the perspective of observing immune cells in intact tumor tissue. Given the technical constraints of multiplex IHC, we aimed to provide the minimum set of most well-established markers enabling identification of each cell type.
A general understating of the steps necessary to optimize IHC for multiple targets is essential to achieve reliable results. So, what are these steps?
Complementary strategies provide vital information regarding antibody specificity or functionality and can be tailored to the nature of the downstream assay.
Bay State Bike Week and the Mass Commute Bicycle Challenge is a great event to promote cycling and build community spirit. CST is looking forward to Bike Week next year where we hope to break the 2,100 mile mark!
A binary approach is one of the best ways to evaluate antibody specificity.
Expert-reviewed diagram providing a current overview of the m6A RNA pathway with references to its role in tumor development
Why not take advantage of our own immune system and the best of its weaponry, the T-cells, to fight cancer? This is the basis of immunotherapy.