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For antigenic targets where expression of the protein is very low or unknown, the use of recombinant proteins or exogenous expression in a surrogate cell line may be necessary for antibody validation.
Validation using recombinant proteins or exogenous expression in a surrogate cell line can be used for targets with low levels of protein expression.
Information and case study data for the PTMScan Direct Cell Cycle and DNA Damage Service offered by CST.
Information and case study data for the PTMScan Direct Ser/Thr Kinases Service, which allows for the targeted screening of a defined set of protein modification sites.
Synopsis of CST scientists' publication in the journal Science Signaling describing phosphorylation patterns associated with non-small cell lung cancer (NSCLC).
This video introduces PTMScan technology, a platform for the enrichment of post-translational modifications (PTMs) in mass spectrometry-based proteomics studies.
A video tutorial illustrating the methodology behind PTMScan Technology and an example of its use in a recent phosphoproteomic study authored by scientists from CST.
Study the intricate machinery of the apoptosis signaling pathway. Click here to learn more and gain insights into programmed cell death mechanisms.
Explore the ERK pathway and its role in cell proliferation and survival. Click here to read more about this critical signaling pathway.
Discover the mTOR pathway and its role in cellular growth and metabolism. Click here to explore the intricacies of this vital signaling pathway.
Overview of MAP Kinase signaling pathways, antibodies and related reagents, interactive pathway diagrams, and other technical resources.
Hallmarks of Antibody Validation: Ranged Strategy. Binary models are not always readily available and can be time-consuming to produce for validating an antibody.
Expert scientist-authored white paper focused on phosphorylation-dependent protein interaction domains in signal transduction.
Resources for the study of Translational Control, Protein Synthesis, and RNA Regulation including antibodies and associated reagents and interactive pathway diagrams.
List of publications based on primary research done by the Cancer Research Group at CST (2002-2013).
A ranged validation strategy includes both endogenous and heterologous models that express high, moderate, and low levels of the target of interest.
Explore the mitochondrial apoptosis pathway and its role in programmed cell death. Read more about this essential pathway here.
Expert-reviewed interactive pathway providing a current overview of Inhibition of Apoptosis Signaling.
Alphabetical listing of protein, pathway, and antibody acronyms, curated by Cell Signaling Technology.
Expert-reviewed interactive pathway providing a current overview of Nuclear Receptor Signaling.
Information and case study data for the PTMScan Direct PI3K/Akt Service offered by CST, which allows for targeted screening of 105 proteins within the Akt pathway.
Overview of apoptosis signaling networks, antibodies and related reagents, interactive pathway diagrams, and technical resources for apoptosis research.
The nuclear receptor signaling plays important roles in cell differentiation, proliferation, metabolism, and other physiological processes. Click here.
Expert-reviewed interactive pathway providing a current overview of Cell Cycle G2/M DNA Damage Signaling.
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.
Study the intricate cell cycle pathway's regulation of cell division and proliferation. Learn more here.
Expert-reviewed interactive pathway providing a current overview of Regulation of eIF4E and p70 S6K.
Explore the G protein coupled receptor signaling pathway and its diverse roles in cellular communication. Read more here.
Expert-reviewed interactive pathway providing a current overview of Regulation of Microtubule Dynamics.
A chronological listing of case studies and peer-reviewed publications utilizing PTMScan proteomic technology developed by Cell Signaling Technology.