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Interested in studying senescence? Understanding cell cycle arrest is critical to many fields of research, including development, aging, and cancer.
Information and case study data for the PTMScan Direct Cell Cycle and DNA Damage Service offered by CST.
Expert-reviewed interactive pathway providing a current overview of Cell Cycle G1/S Checkpoint Signaling.
FastScan ELISA kits detect key signaling proteins using a solution-based assay format and are validated to ensure reproducible results across lots and users.
Study the intricate cell cycle pathway's regulation of cell division and proliferation. Learn more here.
Catalog numbers in tabular format for control cell extracts and proteins with links to product pages.
Cellular senescence is stable cell cycle arrest linked to aging and cancer and other disease states, including those associated with inflammation. It is induced by DNA damage, oncogenic signaling, and telomere shortening.
Stem cell markers and kits organized in table format: links to product pages; includes Oct-4, Sox2, Nanog, c-Myc, C/EBPα, LIN28 and KLF4.
SimpleChIP Kits and Antibodies validated in-house by our antibody development scientists correlated to positive and negative control primers.
Expert-reviewed interactive pathway providing a current overview of T Cell Receptor (TCR) Signaling.
Senescence has been linked to a general decline in tissue function during aging as well as a number of disease states.
Overview of PI3K/Akt signaling pathways, antibodies and related reagents, interactive pathway diagrams, and other technical resources.
Find validated CST® matched antibody pairs and streamline the development of your High-Throughput ELISA-Like Immunoassays for screening.
Expert-reviewed diagram providing a current overview of the Senescence Signaling pathway with references to its role in cell cycle
Senescence is the irreversible arrest of proliferation in response to a variety of cellular stressors. This state is associated with changes in intracellular signaling pathways. Learn more.
Cellular senescence is a state of stable cell cycle arrest under which cells remain metabolically active, but no longer divide or respond to growth-promoting stimuli.
The ESC and Lineage Markers diagram provides an overview of ESC differentiation along lineage-specific pathways and links to products from CST.
Streamline your oncology therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
In response to a variety of environmental factors, cells may permanently cease proliferation and enter a state known as cellular senescence.
Summary of human oncogenes and tumor suppressor genes sorted by signaling pathway.
Cellular senescence is defined by permanent cell cycle arrest. Senescent cells accumulate with age and contribute to normal aging and age-related disorders
p16 is an important cervical cancer biomarker but studies have shown variable expression levels, suggesting an IHC-validated p16 INK4A antibody is needed.
To study pathways regulated by nitrotyrosine, CST offers two recombinant monoclonal antibodies against the same PTM for WB and proteomic applications.
Alphabetical listing of protein, pathway, and antibody acronyms, curated by Cell Signaling Technology.
A scientific resource for the C2 protein domain containing information on structure, function, and binding to phospholipids.
A scientific resource for the SNARE protein domain containing information on structure, function, and binding to mediate protein-protein interactions in vesicle trafficking.
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.
Products and Related Resources for Adaptive Immune Response SARS-CoV-2 Research
A list of important CD markers that includes links to PhosphoSitePlus, Uniprot, and products from Cell Signaling Technology.
The Jak/Stat Utilization Table displays the combinatorial use of tyrosine kinases and Stat proteins in cytokine/growth factor signaling.
