p21Cip1 Antibodies

Target Information

May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding. Belongs to the CDI family. Expressed in all adult tissues, with 5-fold lower levels observed in the brain. Note: This description may include information from UniProtKB.

Alternate Names

CAP; CAP20; CDK; CDK-interacting protein 1; CDK-interaction protein 1; CDKI; Cdkn; CDKN1; Cdkn1; CDKN1A; Cdkn1a; CDN1A; CIP1; Cip1; cyclin dependent kinase inhibitor 1A; Cyclin-dependent kinase inhibitor 1; cyclin-dependent kinase inhibitor 1A (p21, Cip1); cyclin-dependent kinase inhibitor 1A (P21); DNA synthesis inhibitor; mda; MDA-6; MDA6; mda6; melanoma differentiation associated protein 6; Melanoma differentiation-associated protein; Melanoma differentiation-associated protein 6; p21; p21; p21C; p21CIP1; p21Cip1; p21Cip1/Waf1; p21W; p21WAF; PIC1; SDI1; Waf; WAF1; Waf1; wild-type p53-activated fragment 1