CST supports your immunology research with the highest quality antibodies. Immunology-based research focuses on the components of the human immune system and the possibility of their use to combat various diseases.
You need tools to identify and analyze immune cells and immune signaling to advance your research. CST is proud to produce top of the line antibodies for investigating proteins within the complex signaling pathways of the immune system and to contribute to the international movement to develop better, more efficacious therapeutics.
The immune system is comprised of two broad cellular responses:
The innate immune response is your first line of defense against pathogens. It provides a quick response to pathogens by many mechanisms, including cytokine production and complement activation.
The cell types involved in the innate immune response are phagocytic cells: neutrophils, macrophages, natural killer cells, basophils, and others.
As a leader in antibody development, CST has developed a wide array of highly effective antibodies against proteins involved in innate immunity such as the STING, NFκB, and inflammasome signaling pathways.
The adaptive immune response uses antigen-specific receptors to detect foreign antigens. This is a slow occurrence that results from efforts of T Cells, B cells, and natural killer T Cells. Humoral immunity uses antibodies for detection, whereas cell-mediated immunity uses T Cells to destroy the affected cells.
When the antigen is encountered for the first time, lymphocytes exert the primary immune response. The same cells can “learn” from their experience, so that a subsequent encounter with the same antigen will result in a quicker, secondary immune response.
CST has developed a wide array of highly effective antibodies to label the many proteins involved in the lymphocyte signaling pathways, including the TCR and BCR.
The regulation of immune cells occurs through a number of key signaling pathways. Each pathway is comprised of a complex network of proteins that interact with one another to induce a specific cellular response to stimuli.
In addition to the STING, NFƘB, inflammasome, TCR, and BCR signaling pathways, the JAK/STAT and TLR signaling pathways also play major roles in immune cell signaling.