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A scientific resource for the UBA protein domain containing information on structure, function, and domain binding to ubiquitin in protein degradation pathways.
A scientific resource for the ENTH protein domain containing information on structure, function, and domain binding to phospholipids during endocytosis.
Learn here about the HIF-1 signaling pathway and its impact on oxygen homeostasis and cellular adaptation. Click here.
Molecular oxygen is an essential element for metazoan life. Among its many roles, it functions as the final electron acceptor (oxidizing agent) during oxidative phosphorylation, a metabolic chain-reaction that generates energy in the form of ATP. HIF-1 alpha
Meet the aspiring young scientists who won the 4th annual Rising Black Scientists Awards essay competition.
Our summary of recent findings published in Nature, which indicate that non-performing antibodies were used in many recent macular degeneration studies.
Meet the winners of the 3rd annual Rising Black Scientists Awards, an essay competition that supports talented Black American scientists on their journeys.
Happy Holidays, 2017 edition!
Will an antibody validated for WB perform as expected in an IF experiment? Here, we compare an IF-validated mAb from CST to one from another vendor.
Wide selection of validated products to interrogatemechanisms and signaling pathways involved in development,cancer, and degenerative diseases.
Products and Related Resources for Fibrosis SARS-CoV-2 Research
Through the nonprofit Seeding Labs, CST donates lab equipment to research organizations around the world, including a university in Malawi.
Expert-reviewed interactive pathway providing a current overview of Hippo Signaling.
Summary of human oncogenes and tumor suppressor genes sorted by signaling pathway.
It is very difficult to detect HIF-1alpha under normoxic conditions as the protein is quickly degraded. To see strong signal, it is necessary to induce the expression of the protein by either stressing the cells under hypoxic conditions or treating with a hydroxylase inhibitor such as cobalt chloride.
CST Scientist Richard Cho shares his perspective on the 2017 Sf meeting, including new research findings about non-neuronal cells in the brain.
"PI3K/Akt signaling is close to my heart because certain diseases that have cropped up in my family are linked to specific proteins in this pathway."
Reggie Prioli, Associate Director of Conjugation at CST®, has been conjugating antibodies at CST since 2001. Let’s find out why!
YAP is a critical mediator of the Hippo signaling pathway. See a performance comparison of YAP antibodies from CST and 2 other companies.
Resources include signaling pathways, antibodies and companion products, research overviews, technical resources, and recent review articles.
This is a four-part series of tips to improve your ChIP protocol.
We've hit on every aspect of grant writing in these blogs. You may now be wondering: what are my chances? Am I likely to get funded? We dig into the data.
Find Pathways and Diagrams By Disease Area
We’ve put together a starter’s guide on the cellular mechanisms that drive neurodegeneration in diseases such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington’s disease.
Tau is a microtubule-associated protein found in neurons, and its function is to stabilize axonal microtubules. Hyperphosphorylated tau is a hallmark of several neurodegenerative diseases including Alzheimer’s disease.
Dr. Michael J. Comb Receives CiteAb Lifetime Achievement Award
Learn how CUT&RUN can be performed in as little as 1-2 days using low cell number samples, and how CUT&RUN has been employed to study epigenetic remodeling and alternative splicing directed by the NF-κB pathway downstream of a viral oncoprotein.
Cell Signaling Technology CEO and Founder Dr. Michael Comb wins lifetime achievement award.
Cell Signaling Technology pathways by research area