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The 140 kDa band detected by our ATP2A2/SERCA2 Antibody #4388 appears to be consistent with SUMOylation based on Kho, C et al. (2011) Nature 477, 601-5 (PMID: 21900893, https://www.ncbi.nlm.nih.gov/pubmed/21900893). This paper shows that 1) SUMOylation shifts the molecular weight of ATP2A2/SERCA2 from around 100 kDa to around 150 kDa and 2) SUMOylation of ATP2A2/SERCA2 occurs under basal conditions.There are other possible post-translational modifications of ATP2A2/SERCA2 (e.g., phosphorylation, glutathiolation, and nitration), but only SUMOylation would be expected to shift the molecular weight from 110 to 140 kDa.
Overview of Cellular Metabolism pathways, antibodies and related reagents, interactive pathway diagrams, and other technical resources
Learn more about commonly used chemical modulators to study cellular physiology and biology.
Expert-reviewed interactive pathway providing a current overview of ATP-Dependent Chromatin Remodeling Complexes.
Resources include signaling pathways, antibodies and companion products, research overviews, technical resources, and recent review articles.
Find Pathways and Diagrams By Disease Area
Metabolism defines all of the chemical changes or processes within cells, tissues, and organisms that sustain cellular homeostasis.
In an effort to curb carbon emissions, highway congestion and promote employee wellbeing, CST drafted an Alternative Transportation Plan (ATP).
Explore the AMPK pathway and its role in cellular energy homeostasis. Uncover the mechanisms of energy regulation. Learn more here.
Immunoprecipitation Protocol (For Native Protein): easy to follow directions describing the step by step experimental procedure.
Neuroinflammation is a condition observed in the central nervous system (CNS) in response to infection, toxic metabolites, traumatic injury, or autoimmunity.
Expert-reviewed interactive pathway providing a current overview of the Warburg Effect.
Researchers have interrogated BAF complexes for years, but critical roles of chromatin remodelers in cancer and disease have just begun to be elucidated.
Expert-reviewed interactive pathway providing a current overview of Glutamine Metabolism signaling pathway.
A scientific resource for the CARD protein domain containing information on structure, function, and domain binding during apoptosis.
Modulation of CNS function occurs through synaptic neurotransmission, which is the signaling from the axon terminal of one neuron to the dendrites of another via molecules called neurotransmitters.
Cellular homeostasis is regulated by several key metabolic pathways that maintain energetic status and provide the building blocks for proper function.
Overview of epigenetic and chromatin regulation pathways, antibodies and related reagents, interactive pathway diagrams, and technical resources for epigenetics research.
Metabolic processes regulate immune cell function in a process known as immunometabolism, which can be studied using these macrophage and T-cell markers.
Cell viability is a measure of the proportion of live, healthy cells within a population. Assays to assess cell viability measure metabolic activity, ATP content, cell proliferation, or membrane integrity.
Immunoprecipitation Protocol (For Analysis By Kinase Assay): easy to follow directions describing the step by step experimental procedure.
The three main purposes of metabolism are the conversion of food to energy; the conversion of nutrients to proteins, carbohydrates, lipids, and nucleic acids; and the elimination of nitrogenous wastes. There is a strong correlation between metabolic chan
Several different assays can be used by scientists to measure metabolism in a variety of contexts. These include methods to determine metabolic rates, key signaling pathways, and environmental cues.
Cancer cells need a lot of energy to grow fast—to do so, they show abnormal metabolic pathways.
Molecular oxygen is an essential element for metazoan life. Among its many roles, it functions as the final electron acceptor (oxidizing agent) during oxidative phosphorylation, a metabolic chain-reaction that generates energy in the form of ATP. HIF-1 alpha
A list of antibodies directed against chaperones and other proteins involved in Protein Folding offered by Cell Signaling Technology.
Cell viability assays measure the population of live, viable cells within a sample. Typically, viability assays measure markers of cell health, including cellular metabolism, ATP levels, and cell proliferation.
A Hallmark of Cancer, sustaining proliferative signaling is used by cancer cells to stimulate growth and relies on Akt, MAPK/Erk, and MTOR pathways.
We review a recent paper that links TREM2 to microglial function in combatting amyloid plaques, potentially suggesting new targets for Alzheimer's research.
