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Highly specific and sensitive rabbit mAbs against B7 family targets, B7-H3 & B7-H4, are proven to outperform existing clones by WB.
The predicted molecular weight of B7-H4 is 28.8 kDa, but by western blot it is usually observed at 40-80 kDa. This is due to glycosylation of the protein. It is common for a target to shift to higher molecular weights with post-translational modification (e.g., glycosylation). Please see Salceda, S. (2005) et al. Exp Cell Res. 306, 128-41 (PMID 15878339; http://www.ncbi.nlm.nih.gov/pubmed/15878339).
CST offers a growing portfolio of products for the study of immune checkpoint targets in cancer, including several receptor-ligand pairs.
Why not take advantage of our own immune system and the best of its weaponry, the T-cells, to fight cancer? This is the basis of immunotherapy.
Learn how to visualize protein expression in tissue with immunohistochemistry (IHC). See examples of successfully optimized IHC assays.
Cell Signaling Technology Announces the Release of a First to Market IHC-Approved VISTA Antibody
Monoclonal antibodies developed and validated by CST can enable co-detection and spatial characterization of important immune checkpoint control proteins using mIHC
Immunohistochemistry is a method for studying antigen localization in tissue sections using antibodies. Learn sample preparation, labeling, & visualization.
Interact with this diagram showing the epigenetic writers and erasers of histone H2A, histone H2B, and Histone H4, including the involvement of acetyltransferases, deacetylases, methyltransferases, demethylases and kinases.
Resources include signaling pathways, antibodies and companion products, research overviews, technical resources, and recent review articles.
Find Pathways and Diagrams By Disease Area
A scientific resource for the MBT protein domain containing information on structure, function, and binding to methyl-lysine motifs during chromatin regulation.
The Histone Modification Table provides a referenced list of many known histone modifications, associated modifying enzymes, and proposed functions.
Overview of epigenetic and chromatin regulation pathways, antibodies and related reagents, interactive pathway diagrams, and technical resources for epigenetics research.
PD-L1/PD1 immune checkpoint helps tumor cells evade detection by the immune system. Highly specific and sensitive PD-L1 antibody now available from CST.
A scientific resource for the TUDOR protein domain containing information on structure, function, and domain binding to methylated-lysine residues in chromatin remodeling.
Interact with this signaling pathway showing immune checkpoint regulation in the tumor microenvironment, including targets such as PD-L1, GITR, TIM-3, CTLA-4, OX40, and more.
SimpleChIP Kits and Antibodies validated in-house by our antibody development scientists correlated to positive and negative control primers.
Histone modification antibodies are validated using a peptide array assay at CST
3D video animation of histone modifications and their effects on chromatin activation
A scientific resource for the BROMO protein domain containing information on structure, function, and binding to acetylated-lysine residues during chromatin remodeling.
Products and Related Resources for Adaptive Immune Response SARS-CoV-2 Research
Cell Signaling Technology pathways by research area
Streamline your neurodegeneration therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
The ESC and Lineage Markers diagram provides an overview of ESC differentiation along lineage-specific pathways and links to products from CST.
Expert-reviewed interactive pathway providing a current overview of Histone Methylation.
Find validated CST® matched antibody pairs and streamline the development of your High-Throughput ELISA-Like Immunoassays for screening.
Use our protocol compatibility table to understand which immune signaling and phenotyping antibodies will work together in your multicolor flow cytometry experiment.
Compare Cell Signaling Technology's Akt antibodies against one another to determine optimal applications
