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Information and case study data for the PTMScan Direct PI3K/Akt Service offered by CST, which allows for targeted screening of 105 proteins within the Akt pathway.
Information and case study data for the PTMScan Direct Tyrosine Kinases Service from Cell Signaling Technology.
A scientific resource for the RING protein domain containing information on structure, function, and domain binding to ubiquitin in protein degradation pathways.
Cell Signaling Technology, Inc. (CST) of Danvers, MA, announced today that it has introduced a highly specific PD-L1 rabbit monoclonal antibody (mAb).
Dako and Cell Signaling Technology (CST) today announced that they have entered into a strategic partnership to supply antibodies for use in Dako-branded companion diagnostics products.
Information and case study data for the PTMScan Direct Cell Cycle and DNA Damage Service offered by CST.
Cellular senescence is stable cell cycle arrest linked to aging and cancer and other disease states, including those associated with inflammation. It is induced by DNA damage, oncogenic signaling, and telomere shortening.
Find validated CST® matched antibody pairs and streamline the development of your High-Throughput ELISA-Like Immunoassays for screening.
The PI3K / Akt Substrates Table provides a comprehensive list of demonstrated downstream targets of Akt phosphorylation.
Cell Signaling Technology, Inc. (CST) is ISO 9001:2008 certified for the design, development, and production of monoclonal antibodies (mAbs).
We have no specific tips for using FACS-isolated cells in CUT&RUN experiments. Like a cultured cell suspension, if your isolated cells are in less than 40ul PBS, you can move directly to Concanavalin A bead binding by adding wash buffer for a total of 100ul per reaction. Otherwise, you need to either spin the cells and remove some of the PBS or add wash buffer and Concanavalin A beads proportionally based on the volume of PBS you have in your sorted cell sample. In our experience, the Concanavalin A beads do not bind to cells in the pure PBS environment.
Technical support questions and issues for flow cytometry-validated antibodies and products from CST Cell Signaling Technology
Get information on ordering or contacting Cell Signaling Technology. CST is happy to answer your questions. Select the team you need to contact.
Cell Signaling Technology, a leading provider of antibodies, kits and services, announced today that it has won two Life Science Industry Awards® for "Best Antibodies" and "Most Useful Website."
Troubleshooting tips for successfully performing Intracellular Flow Cytometry using CST recommended protocols and antibodies validated for Flow.
In humans, there is a PTEN long isoform (isoform alpha) that can potentially be detected by our PTEN (D4.3) XP Rabbit mAb #9188 and PTEN (138G6) Rabbit mAb #9559 based on sequence homology. There is also a paper that cites #9559 specifically detecting the long isoform of PTEN. [see H. Liang et. al (2014) Cell Metab. 19, 836-48, PMID: 24768297, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097321]
Illustration of Motif Antibody Coverage
Cancer cells can resist death. They evade apoptosis, the mechanism that programs cell death once cells become damaged. Normally, apoptosis helps keep an organism healthy through growth and development, but cancer cells do not follow this process, no matter how abnormally they grow.
Jak and cytokine receptor mutations found in various cancers, along with the corresponding PubMed reference(s).
Bmi1 undergoes numerous post-translational modifications and can be heavily phosphorylated, as described on the PhosphoSite.org protein page (https://www.phosphosite.org/proteinAction.action?id=1286622&showAllSites=true). Therefore, we believe the upper band represents phosphorylated Bmi1.Multiple papers have also described Bmi1 migrating as a doublet by western blot, as shown in the examples below.
SignalScan bridges the gap between PCR-based detection of COVID-19 infection and uncovering the molecular signature of infection and host immune response.
Overview of GPCR, Calcium, cAMP Signaling Resources, interactive pathway diagrams, and other technical resources.
At CST, we produce the majority of our antibodies in-house, so over 99.5% of our products are always available for immediate shipment from the US.
Rapid-act anti-CD3/CD28 T cell activation and expansion kits stimulate activation in one step for studying early and/or short-lived signaling events.
