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T cells are essential to cell-mediated immunity. Recognition of an antigen and engagement of a variable T cell receptor that is expressed on the cell surface leads to T cell activation.
Cell viability assays measure the population of live, viable cells within a sample. Typically, viability assays measure markers of cell health, including cellular metabolism, ATP levels, and cell proliferation.
B cells are lymphocytes that are an important part of the humoral immune response. The main role of B cells is to produce antibodies in response to antigens.
The immune system is composed of tissues, cells, and molecules whose primary function is to detect, respond to, and eliminate pathogens and transformed cells.
Apoptosis is a type of programmed cell death that occurs normally throughout the lifespan and can also occur in response to harmful stimuli. Apoptotic cells are identified by their altered morphology, caspase activation, and the presence of damaged DNA.
The adaptive immune response uses antigen-specific receptors to detect foreign antigens. This is a slow occurrence that results from efforts of T cells, B cells, and natural killer T cells.
Cell viability is a measure of the proportion of live, healthy cells within a population. Assays to assess cell viability measure metabolic activity, ATP content, cell proliferation, or membrane integrity.
Myeloid cells are differentiated from hematopoietic stem cells in the bone marrow and include monocytes, macrophages, neutrophils, basophils, eosinophils, erythrocytes, megakaryocytes, and platelets.
Resources include signaling pathways, antibodies and companion products, research overviews, technical resources, and recent review articles.
Many cell cycle and proliferation assays exist to measure the amount and rate of cell division. Proliferation can be used as a marker for cell viability.
The comprehensive CST catalog of rigorously tested and validated products related to cell cycle regulation, DNA damage, and cell death and viability.
This post explores common T cell types, their roles in modulating immune cell response, and T cell activation via interaction with cell surface receptors.
Cell counting is essential for monitoring cell health and proliferation. Learn how to count accurately and determine cell density and percent viability.
Immunophenotyping is a technique that uses antibodies to allow the identification and quantification of particular cell types within a heterogenous population.
Cell Signaling Technology, Inc. Announces License in Personalized Cancer Diagnostics.
Resazurin assay protocol, a simple and sensitive way to measure cell viability. Our step-by-step protocol is easy to follow & produces reproducible results.
Cell Signaling Technology Expands in China
Overview of stem cell markers, lineage markers, development and differentiation signaling networks at Cell Signaling Technology.
Lymphoid lineage cells can be characterized using antibodies for cell type-specific markers, allowing cells to be visualized using flow cytometry or IHC.
Study the intricate cell cycle pathway's regulation of cell division and proliferation. Learn more here.
Cell Signaling Technology (CST) Enters Agreement with Roche for CDx Development
With adherent cell lines, one first needs to detach the cells from the dish. We recommend using trypsin to detach the cells. Alternatively, you can use accutase, but the resulting cell pellet doesn't pack as well during centrifugation, so you tend to lose cells during the wash steps. Suspension cells are much easier. Just count the cells using a hemacytometer or auto cell counter and then collect the number of cells you need. We don't observe a significant difference in assay performance with adherent versus suspension cells.
Cell Signaling Technology (CST) Drives Sustainability in the Life Sciences Through My Green Lab Sponsorship
Did you know that an estimated 18-36% of lab cell lines are believed to be misidentified or cross-contaminated with another cell line?
Distinguish living cells from dead or dying cells with viability dyes.