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Overview of autophagy signaling, antibodies and related reagents, interactive pathway diagrams, and technical resources for autophagy research.
Discover the autophagy pathway and its crucial role in cellular homeostasis. Learn more and uncover the mechanisms of cellular self-degradation here.
Autophagy helps normal cells maintain homeostasis and acts as a survival mechanism in response to stress, where ULK1 plays an important role in signaling.
Products and Related Resources for Cell Death and Viability SARS-CoV-2 Research
Autophagy is more than just the bulk degradation of intracellular components. It can also selectively degrade specific organelles, pathogens, and proteins.
PD is characterized by functional loss in dopaminergic neurons, believed to be caused by disruption of proteins involved in cell quality control pathways.
The antigenic peptides used to produce our Atg4B (D1G2R) Rabbit mAb #13507, our Atg4B Antibody #5299, our Phospho-Atg4B (Ser383) Antibody #19386, and our Phospho-Atg4B (Ser383) (E3I8M) Rabbit mAb #40592 share little to no sequence identity with the Atg4A, Atg4C, and Atg4D paralogs. Therefore, they are unlikely to cross-react with these paralogs.
该视频将将逐一介绍参与自噬信号通路的关键分子,包括ULK1 、Beclin1、LC3、Atg5,ATG12,P62等
Information and case study data for the PTMScan Direct Apoptosis/Autophagy Service offered by CST.
LC3 exists as three highly homologous isoforms or paralogs. These are LC3A, LC3B, and LC3C. These LC3 paralogs have different patterns of expression in human tissues [see He, H et al. (2003) J Biol Chem 278(31), 29278-87 (PMID 12740394 Figure 2A; http://www.ncbi.nlm.nih.gov/pubmed/12740394)] and undergo post-translational modifications during autophagy. Cleavage of LC3 (i.e., LC3A, LC3B, and/or LC3C) at the carboxy terminus immediately following synthesis yields the cytosolic LC3-I form. During autophagy, LC3-I is converted to LC3-II through lipidation by a ubiquitin-like system involving Atg7 and Atg3 that allows for LC3 to become associated with autophagic vesicles. The presence of LC3 in autophagosomes and the conversion of LC3 to the lower migrating form LC3-II are used as markers of autophagy.
Webinar featuring Reuben Shaw, Professor at the Molecular and Cell Biology Laboratory, Deputy Director of Salk Cancer Center, Salk Institute for Biological Studies.
Cancer cells resist inhibitory signals that might otherwise stop their growth. The major pathways involved are Autophagy and Apoptosis.
Drs. Cominelli and Kugathasan describe new techniques to identify and target inflammatory signaling in gastrointestinal immune cells in this webinar.
The regulation of ER stress and autophagy during viral infection is an important factor in the balance of virus and host survival.
Find validated CST® matched antibody pairs and streamline the development of your High-Throughput ELISA-Like Immunoassays for screening.
Xenophagy provides an important defense against foreign pathogens such as bacteria and viruses by targeting them for degradation through autophagy.
Expert-reviewed interactive pathway providing a current overview of the Inflammasome Signaling Pathway.
Organelle markers for immunofluorescence analysis from CST Cell Signaling Technology
Streamline your oncology therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
KinomeView® Profiling Kit and Services
Illustration of Motif Antibody Coverage
Information and case study data for the PTMScan Direct Cell Cycle and DNA Damage Service offered by CST.
PhosphoScan® Phosphorylation Proteomics
In response to a variety of environmental factors, cells may permanently cease proliferation and enter a state known as cellular senescence.
Expert-reviewed interactive pathway providing a current overview of Cell Cycle G2/M DNA Damage Signaling.
Senescence is the irreversible arrest of proliferation in response to a variety of cellular stressors. This state is associated with changes in intracellular signaling pathways. Learn more.
PTMScan Motif Antibodies and Kits, for customers who purchase a license and would like to perform PTMScan Proteomics in-house.
Study the intricate cell cycle pathway's regulation of cell division and proliferation. Learn more here.